Tracing the evolution of tissue inhibitor of metalloproteinases in Metazoa with the Pteria penguin genome
Summary: Tissue inhibitors of metalloproteinase (TIMPs) play a pivotal role in regulating extracellular matrix (ECM) dynamics and have been extensively studied in vertebrates.However, understanding their evolution across invertebrate phyla is limited.Utilizing the high-quality Pteria penguin genome, we conducted phylogenomic orthology analyses acro